Altoona is an unincorporated census-designated place in Lake County, Florida. The population was 88 at the2000 United States Census. It is part of the Orlando–Kissimmee–Sanford Metropolitan Statistical Area.According to the United States Census Bureau, the CDP has a total area of 0.5 square miles (1.3 km2), of which, 0.4 square miles (1.0 km2) of it is land and 0.1 square miles (0.26 km2) of it (12.00%) is water.
Altoona was either named after Thomas Jefferson Hinson's hometown of Allatoona, Georgia, or after Altoona, Pennsylvania, which was the hometown of Augustus Gottschee, the first merchant in this settlement. Altoona became an incorporated municipality on February 12, 1887. The town was abolished on May 27, 1899, following a fire that wiped out most of its buildings and reduced its tax base to near zero.