Apopka is a city in Orange County, Florida. The city's population was 41,542 at the 2010 census, up from 26,969 at the 2000 U.S. Census.
The earliest known inhabitants of the Apopka area were the Acuera people, members of the Timucua confederation. They had disappeared by 1730, probably decimated by diseases brought to Florida by Spanish colonists.The Acuera were succeeded by refugees from Alabama and Georgia, who formed the new Seminole Indian tribe. They called the area Ahapopka.The early American settlers built a major trading center on the foundations of the earlier Indian settlement. Their population was large enough by 1857 to support the establishment of a Masonic lodge. In 1859 the lodge erected a permanent meeting place at what is now the intersection of Main Street (U.S. Highway 441) and Alabama Avenue.In 1905, the Apopka City Council authorized incorporation of the Apopka Water, Light, and Ice Company.