Sanford is a city in the central region of the U.S. state of Florida. It is the county seat of Seminole County. As of the 2010 census, the city had a population of 53,570.
The Mayaca or Jororo Indians inhabited the shores of Lake Monroe at the time of European contact. By 1760, however, war and disease had decimated the tribe, which would be replaced by the Seminole Indians. Florida was acquired by the United States from Spain in 1821, but the Seminole Wars would delay settlement. In 1835, the Seminoles burned the port of Palatka on the St. Johns River, then the major artery into Central Florida from the East Coast. Consequently, an army garrison was established upstream, on the southern side of Lake Monroe near a trading post. Called Camp Monroe, the log breastwork was attacked on February 8, 1837. It would be strengthened and renamed Fort Mellon in honor of Captain Charles Mellon, the sole American casualty.