Frederick is a city and the county seat of Frederick County in the State of Maryland. Frederick has been an important crossroads community since it was located in colonial times at the intersection of an important north–south Indian trail, and east–west routes to the Chesapeake Bay both at Baltimore and what became Washington, D.C. and across the Appalachian mountains to the Ohio River watershed.
Located where Catoctin Mountain (the easternmost ridge of the Blue Ridge mountains) meets the rolling hills of the Piedmont region, the Frederick area became a crossroads even before European explorers and traders arrived. Native American hunters (known to Virginia colonists as "Susquehannocks", which might be Algonquian-speaking Shawnee or more likely Seneca or Tuscarora or other members of theIroquois Confederation) followed the Monocacy River from the Susquehanna River watershed in Pennsylvania to the Potomac Riverwatershed and the lands of the more agrarian and maritime Algonquian peoples, particularly the Lenape of the Delaware valley or thePiscataway or Powhatan of the lower Potomac watershed and Chesapeake Bay. This became known as the Monocacy Trail or even theGreat Indian Warpath, with some travelers continuing southward through the "Great Appalachian Valley" (Shenandoah Valley, etc.) to the western Piedmont in North Carolina, or traveling down other watersheds in Virginia toward the Chesapeake Bay, such as those of theRappahannock, James and York Rivers.