Hartsville is a town in Trousdale County, Tennessee, United States. It is the county seat of Trousdale County, with which it shares a consolidated city-county government. The population of Hartsville was 2,369 as of 2010.
The first Euro-American settlers arrived in what is now Hartsville in 1797, when the family of James Hart settled along the west bank of the West Fork of Goose Creek, and the family of Charles Donoho settled along the creek's east bank. Donoho erected a mill shortly thereafter, and the town was initially known as Donoho's Mill. James Hart established Hart's Ferry along the Cumberland River several miles to the south, and purchased the Donoho property in 1800. Hartsville was officially recognized as a town in 1817. Donoho's Mill, on the east bank of the creek, had become known as "Damascus," although it merged with Hartsville in 1840 when Hartsville officially incorporated. During the Civil War, Hartsville was site of the Battle of Hartsville, which took place in 1862.