Devine is a city in Medina County, Texas, United States. The population was 4,350 at the 2010 census. It is part of the San Antonio Metropolitan Statistical Area. Devine, Texas, is named for Hon. Thomas J. Devine, a native of San Antonio. This is 25 miles southwest of Downtown San Antonio. According to the United States Census Bureau, the city has a total area of 3.1 square miles (8.0 km2), all of it land.