Potrero is a census-designated place in the Mountain Empire area of southeastern San Diego County, California.
State Route 94 connects Potrero by road west to San Diego and east to Campo. Potrero is Spanish for 'pasture land'. Its closest neighbor is Tecate, in Mexico.
According to the United States Census Bureau, the CDP covers an area of 3.1 square miles (8.2 km²), all of it land.