Killarney is an unincorporated community in Orange County, Florida, United States.The community is located west of Oakland, south of Lake Apopka, north of John's Lake, and east of the Lake-Orange County Line.The main roads through Killarney are State Road 50, Old CR 50, and County Road 438. The West Orange Trailand South Lake-Lake Minneola Scenic Trail terminate within the community. Florida's Turnpike also runs though Killarney, but has no interchanges there. The nearest interchange is with SR 50 in nearby Oakland.A post office called Killarney was established in 1887. The community was named after Killarney, in Ireland.