Lytle is a city in Atascosa, Bexar, and Medina counties in the U.S. state of Texas. The population was 2,492 at the 2010 census. It is part of the San Antonio Metropolitan Statistical Area. According to the United States Census Bureau, Lytle has a total area of 4.1 square miles (10.5 km2), of which 4.0 square miles (10.4 km2) is land and 0.039 square miles (0.1 km2), or 1.08%, is water. Lytle was founded in 1882 by cattleman Captain John T. Lytle after a railroad station was established in the area, and was incorporated on October 27, 1951.