Seguin is a city in and the county seat of Guadalupe County, Texas, United States. The estimated municipal population in 2012 was 26,272.
The Seguin area was once inhabited by the native hunter-gatherer Indians of Texas. An ongoing archeological dig indicates campgrounds dating back 10,000 years or so, with trade items from Mexico and Arizona. By the time the first European explorers passed through, predominantly Tonkawas lived in the area, camping around the Guadalupe and other streams in the area. Eventually Spanish, Mexican, and Anglo settlers started farms and ranches in the location that would become Seguin.Jose Antonio Navarro, one of the earliest settlers and an important figure of Texas history, developed a ranch near Seguin. In 1831, land was granted to Umphries Branch by the Mexican government. The Branch and John Newton Sowell Sr. families settled in 1833 in the western part of Green DeWitt's colony.Sowell was a farmer, and in 1833 he and his brothers became the first Anglo-American immigrants to raise corn in future Guadalupe County.The town of Seguin was founded August 12, 1838, 16 months after Texas won its independence at the Battle of San Jacinto, making it one of the oldest towns in Texas. At this time the Seguin area was a part of Gonzales County.