Seguin is a city in and the county seat of Guadalupe County, Texas, United States. The estimated municipal population in 2012 was 26,272.
The Seguin area was once inhabited by the native hunter-gatherer Indians of Texas. Jose Antonio Navarro, one of the earliest settlers and an important figure of Texas history, developed a ranch near Seguin. In 1831, land was granted to Umphries Branch by the Mexican government. The Branch and John Newton Sowell Sr. families settled in 1833 in the western part of Green DeWitt's colony.Sowell was a farmer, and in 1833 he and his brothers became the first Anglo-American immigrants to raise corn in future Guadalupe County.Between 1827 and 1835, twenty-two families came to the area as part of the DeWitt Colony; by 1833 there were forty land titles in the region, fourteen of which received grants directly from the Mexican government. In 1836, John Gladden King lived near Seguin. His farm neighbored the Sowells on the northwest and Branch on the southeast. A son, William Philip King, reportedly was part of a cannon crew and was the youngest defender killed during the battle of the Alamo.These homesteads were abandoned in the Runaway Scrape.The town of Seguin was founded August 12, 1838, 16 months after Texas won its independence at the Battle of San Jacinto, making it one of the oldest towns in Texas. Members of Mathew Caldwell's Gonzales Rangers acquired land originally granted to Umphries Branch, who had departed during the Runaway Scrape and sold his land to Joseph S. Martin.Seguin was named the county seat, and Guadalupe County was organized, early in 1845, as Texas became a state. The first county judge was Michael H. Erskine. The town was incorporated in 1853, and a city government was organized under acting Mayor John R. King, until elections were held later that year and John D. Anderson became the first elected mayor.